Society/Host Colloquium: Transport of Small Molecules Across Plasrna Membranes Organized and Edited by S. P. Shirazi-Beechey (Aberystwyth); Mechanisms of Transport of Proteins Across Biological Membranes Organized and Edited by M. A. Kaderbhai (Aberystwyth) Epithelial electrolyte transport: interrelationships
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Abbreviations used: BCECF, 2',7'-bis(carboxyethyl)-5(6')carboxyfluorescein; ACh, acetylcholine; DIDS, 4,4'-di-isothiocyanatostilbene-2.2'-disulphonic acid. the basolateral (contraluminal) membrane; for secretion the sequence is reversed. Quantitatively, ions and water dominate the transport activity of most epithelia. Although the species of ions transported and the direction of transport may differ, this diversity of function seems to be achieved through the co-ordinated activity of a relatively small number of transport proteins (pumps, carriers and channels), which are combined in different proportions and at different cellular locations (i.e. apical or basolateral membranes) in different epithelia. Those commonly involved are listed in Table 1 . A general description of the function and regulation of these transport proteins has been published elsewhere [ 11, while a detailed description of some of them follows in this
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